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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by What The Dillio on March 14, 2002, at 1:14:06
I have been on Amoxapine (Asendin, an atypical tricyclic) for 2 1/2 weeks. It is still too early to determine whether or not it has an antidepressant effect for me.
Overall, the side-effect profile is benign. There is no sedation, and there are no sexual side-effects. Weight gain is generally not an issue with Amoxapine. Anticholinergic effects (constipation, dry mouth, etc) are mild, definitely less than those that occur with SSRIs.
Unfortunately, I did experience a few ExtraPyramidal Side-effects. These occur with amoxapine because it has a mild tranquilizer component, although this component is much weaker than most neuroleptics. I had some Restless Legs, but only because I took excessive doses of it. With the start of the third week, this side-effect went away spontaneously.
No newer antidepressant has been proven more effective than a tricyclic in the treatment-resistant case, so if you're in this category, chances are good that a tricyclic may benefit you greatly. Consider amoxapine an more tolerable alternative to the other classical tricyclics.
Posted by IsoM on March 14, 2002, at 1:27:43
In reply to Amoxapine As An Alternative to Dirty Tricyclics, posted by What The Dillio on March 14, 2002, at 1:14:06
I took it for a long time a number of years ago & found it worked well. I think it is probably too overlooked by many from the few bad effects some have had on it. But I found dry mouth & constipation worse for me than with SSRIs.
This is the end of the thread.
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