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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by BrittPark on December 6, 2002, at 16:50:27
I've been googling and medlining trying to find out how long, on average, it takes for a person to regain opioid sensitivity after discontinuation of chronic administration. Anybody know?
Curiously,
Britt
Posted by oracle on December 6, 2002, at 16:57:42
In reply to Opioid Sensitivity?, posted by BrittPark on December 6, 2002, at 16:50:27
for a person to regain opioid sensitivity after discontinuation of chronic administration. Anybody know?
Define "opioid sensitivity"
Posted by BrittPark on December 6, 2002, at 17:18:33
In reply to Re: Opioid Sensitivity?, posted by oracle on December 6, 2002, at 16:57:42
> for a person to regain opioid sensitivity after discontinuation of chronic administration. Anybody know?
>
>
> Define "opioid sensitivity"Sorry, I didn't think it needed a definition. I meant normal analgesic and euphoric response to opioids.
For example I've had two surgeries after each of which I was prescribed vicodin. After the first surgery I took vicodin 7.5s qid at least. Within a few days, the euphoric effect disappeared. Months later I had the second surgery and afterwards found that the vicodin not only provided adequate analgesia but the same euphoric effect as when I had first taken it. By the the time of my second surgery I had regained "opioid sensitivity". That's what I meant.
Cheers,
Britt
Posted by oracle on December 6, 2002, at 18:19:57
In reply to Re: Opioid Sensitivity? » oracle, posted by BrittPark on December 6, 2002, at 17:18:33
> > for a person to regain opioid sensitivity after discontinuation of chronic administration. Anybody know?
> >
> >
> > Define "opioid sensitivity"
>
> Sorry, I didn't think it needed a definition. II think you are looking for "tolerance".
Posted by BrittPark on December 6, 2002, at 18:23:52
In reply to Re: Opioid Sensitivity?, posted by oracle on December 6, 2002, at 18:19:57
No, I meant sensitivity. Take a look at my previous post.
Cheers,
Britt
Posted by ShelliR on December 7, 2002, at 17:00:19
In reply to Re: Opioid Sensitivity? » oracle, posted by BrittPark on December 6, 2002, at 18:23:52
Britt,
I still can't really separate opiate tolerance from opiate sensitivity in your posts. I think they are very much related.The answer is dependent on how much you increased you dose of opiates (if at all), and how long you took them for. And different people react differently.
I was on oxycontin a long time, started on a very small dose and worked my way up very quickly. Now if I try it again I still get the opiate high at the very beginning, but only for a short time. Since I didn't care about the high anyway, it is more upsetting that I also find that although a small dose works for pain the next time, it lasts only for a couple of days then I have to go up much quicker then I had previously with the same amount of pain. (And the feeling of "high" on the same dose, lasts a very very short time).
I definitely feel that being on a large dose created a tolerance in my body to opiates. It's a little tricky because they seem to work the same when I try again, but I become habituated much much quicker: in a few days I am up to the amount it took me months to get to the first time to combat the same level of pain. My pain doctor said that is not the case with everyone, but I have talked to others with the same experience.
Shelli
Posted by BrittPark on December 7, 2002, at 19:37:50
In reply to Re: Opioid Sensitivity? » BrittPark, posted by ShelliR on December 7, 2002, at 17:00:19
This is the end of the thread.
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