Psycho-Babble Medication Thread 390513

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wellbutrin - sleepiness and fog

Posted by lois on September 13, 2004, at 21:57:35

Wellbutrin puts me into a fog and I can nap all day.
Any one else have this paradoxical reaction, or know why I might react like this?
I am also, among other stablizers, on
lexapro (decreased to 40, and topomax(decreased to 100mgs) to help increase alertness
without much difference.
Plan to stay on W.B. amd add Abilify.
(Provigil did not help.)
Any iput?
Thx.
Lois

Re: wellbutrin - sleepiness and fog

Posted by King Vultan on September 13, 2004, at 23:20:44

In reply to wellbutrin - sleepiness and fog, posted by lois on September 13, 2004, at 21:57:35

> Wellbutrin puts me into a fog and I can nap all day.
> Any one else have this paradoxical reaction, or know why I might react like this?
> I am also, among other stablizers, on
> lexapro (decreased to 40, and topomax(decreased to 100mgs) to help increase alertness
> without much difference.
> Plan to stay on W.B. amd add Abilify.
> (Provigil did not help.)
> Any iput?
> Thx.
> Lois

There is a theory that people who become sedated from taking stimulating dopaminergic drugs have a problem with hypersensitive dopamine autoreceptors. That be said, I don't know if Wellbutrin quite qualifies, but Provigil would, as would the amphetamines. In my case, I reacted fairly normally to Wellbutrin, experiencing a "wired" effect and insomnia at first that went away after a week or so. I never found Wellbutrin outright sedating but was able to take the 2nd dose of 2 x 150 mg/day of the SR version right at bedtime and sleep like a log, which I don't believe most people are able to do.

OTOH, Provigil made me extremely sedated and barely able to function, which lends credence to me having this hypersensitive autoreceptor thing. I am currently taking Parnate, which is not sedating for me and which I am hopeful will downregulate these receptors, realizing, of course, that this is just a hypothesis as to what's going on. I'm afraid I completely lack familiarity with mood stabilizers and have no idea what effect that might be having in your situation.

Todd

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