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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by willyee on May 27, 2005, at 15:03:13
Hey guys,
I recently read that parnate is now considered a REVERSABLE MAOI.If this is the case,why would say taking Nardil in the morning and parnate hours thereafter,has im not suggesting this to anyone just curious if anyone might have exper this phenom.We write it off cause medically it seems deadly,and so it might be,but what if it isnt,i say this cause i mentioned time and again about having a great response to parnate the day after my nardil trial was cut.
Posted by Maxime on May 27, 2005, at 19:16:52
In reply to I could really use an answer, posted by willyee on May 27, 2005, at 15:03:13
Where did you read this and what criteria did they use. I would like to read the article.
Maxime
> Hey guys,
>
> I recently read that parnate is now considered a REVERSABLE MAOI.If this is the case,why would say taking Nardil in the morning and parnate hours thereafter,has im not suggesting this to anyone just curious if anyone might have exper this phenom.
>
> We write it off cause medically it seems deadly,and so it might be,but what if it isnt,i say this cause i mentioned time and again about having a great response to parnate the day after my nardil trial was cut.
Posted by willyee on May 28, 2005, at 0:07:39
In reply to Re: I could really use an answer » willyee, posted by Maxime on May 27, 2005, at 19:16:52
> Where did you read this and what criteria did they use. I would like to read the article.
>
> Maxime
>
>
> > Hey guys,
> >
> > I recently read that parnate is now considered a REVERSABLE MAOI.If this is the case,why would say taking Nardil in the morning and parnate hours thereafter,has im not suggesting this to anyone just curious if anyone might have exper this phenom.
> >
> > We write it off cause medically it seems deadly,and so it might be,but what if it isnt,i say this cause i mentioned time and again about having a great response to parnate the day after my nardil trial was cut.
>
>Its spread out in various sites on a google search this is on page one
Heres the snip its in the second paragraph:
Tranylcypromine differs from other MAO inhibitors in being a reversible inhibitor. When tranylcypromine is withdrawn, monoamine oxidase activity is generally restored within a week, although the drug is excreted in 24 hours.
Posted by Maxime on May 29, 2005, at 15:59:44
In reply to Re: I could really use an answer, posted by willyee on May 28, 2005, at 0:07:39
Thanks. I actually wrote to WebMD and asked them why they said it was reversible. Then I came across the following:
_____________________
Irreversible MAO-A and MAO-B Inhibitor (MAO-IA,IB)
The non-selective inhibition of both MAO-B and MAO-B produces an increase in the concentration
of serotonin, norepinephrine, and dopamine in the brain. The broad-spectrum boost in neurotransmitter
chemistry provides a powerful antidepressant e ect. It also provides for some of the negative
side e ects; this category of medications, like others that boost serotonin levels, tend to impair or
suppress libido and sexual function.
Tranylcypromine is most often described as an irreversible inhibitor of both MAO-A and MAOB,
although there are a few references which contradict this assertion and claim that it is reversible.
In any event, the washout times cited are more like those of irreversible MAO inhibitors, so it will
be considered irreversible here.
__________So I guess the jury is out on this one!
Thanks for posting about it. It's interesting.
Maxime
> > Where did you read this and what criteria did they use. I would like to read the article.
> >
> > Maxime
> >
> >
> > > Hey guys,
> > >
> > > I recently read that parnate is now considered a REVERSABLE MAOI.If this is the case,why would say taking Nardil in the morning and parnate hours thereafter,has im not suggesting this to anyone just curious if anyone might have exper this phenom.
> > >
> > > We write it off cause medically it seems deadly,and so it might be,but what if it isnt,i say this cause i mentioned time and again about having a great response to parnate the day after my nardil trial was cut.
> >
> >
>
> Its spread out in various sites on a google search this is on page one
>
> http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS-%20Monographs/CPS-%20(General%20Monographs-%20P)/PARNATE.html
>
>
> Heres the snip its in the second paragraph:
>
>
> Tranylcypromine differs from other MAO inhibitors in being a reversible inhibitor. When tranylcypromine is withdrawn, monoamine oxidase activity is generally restored within a week, although the drug is excreted in 24 hours.
>
>
Posted by Chairman_MAO on May 30, 2005, at 20:14:40
In reply to I could really use an answer, posted by willyee on May 27, 2005, at 15:03:13
FWIW, I started Nardil the same day I took 150mg Parnate in the morning. No washout, no problems whatsoever (my doctor did not think a washout was necessary, either, despite all of the dire warnings). NOTE: Nardil's GABA-T inhibitory effect is a result of a metabolite formed by MAO-B (I think). If you take tranylcypromine with it, there is a chance you will attenuate that effect.
Posted by willyee on May 30, 2005, at 21:58:00
In reply to Re: I could really use an answer » willyee, posted by Chairman_MAO on May 30, 2005, at 20:14:40
> FWIW, I started Nardil the same day I took 150mg Parnate in the morning. No washout, no problems whatsoever (my doctor did not think a washout was necessary, either, despite all of the dire warnings). NOTE: Nardil's GABA-T inhibitory effect is a result of a metabolite formed by MAO-B (I think). If you take tranylcypromine with it, there is a chance you will attenuate that effect.
An answer THANK YOUUUUUUUUUU
Posted by Maxime on May 31, 2005, at 9:39:14
In reply to Re: I could really use an answer » willyee, posted by Chairman_MAO on May 30, 2005, at 20:14:40
> FWIW, I started Nardil the same day I took 150mg Parnate in the morning. No washout, no problems whatsoever (my doctor did not think a washout was necessary, either, despite all of the dire warnings). NOTE: Nardil's GABA-T inhibitory effect is a result of a metabolite formed by MAO-B (I think). If you take tranylcypromine with it, there is a chance you will attenuate that effect.
Phew, it's good to know that my doctor wasn't the only one who did this.
Does this mean then that it would be safe to take the two together on a regular basis?
Maxime
This is the end of the thread.
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