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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by flip_flop on August 20, 2006, at 3:47:59
Since amisulpride, an antipsychotic, can cause elevated prolactin levels, would adding a D2 agonist (to normalize prolactin levels) cause the antipsychotic effects from amisulpride to diminish? Amisulpride has high affinity for D2 and D3 receptors.
Posted by linkadge on August 20, 2006, at 15:05:34
In reply to Would a D2 agonist make an AP inefficient?, posted by flip_flop on August 20, 2006, at 3:47:59
While it may reduce the antipsychotic effect of the drug, I don't think it will reduce effects of the drug entirely.
Linkadge
Posted by SLS on August 21, 2006, at 10:15:52
In reply to Would a D2 agonist make an AP inefficient?, posted by flip_flop on August 20, 2006, at 3:47:59
> Since amisulpride, an antipsychotic, can cause elevated prolactin levels, would adding a D2 agonist (to normalize prolactin levels) cause the antipsychotic effects from amisulpride to diminish? Amisulpride has high affinity for D2 and D3 receptors.
APs are sometimes given to Parkinsons patients who have developed psychosis during treatment with DA agonists. Unfortunately, with the exceptions of clozapine and possibly quetiapine, they often worsen motor symptoms. Both quetiapine and clozapine have very low affinities for D2 receptors and can still be effective as a treatment in this situation. This might indicate that these drugs still exert antipsychotic effects in the presence of DA agonists.
- Scott
Posted by blueberry on August 21, 2006, at 12:23:02
In reply to Would a D2 agonist make an AP inefficient?, posted by flip_flop on August 20, 2006, at 3:47:59
At pubmed.com I remember reading some abstracts where the D2 agonist bromocriptine was added to amisulpride for the purpose of normalizing prolactin levels. It did normalize prolactin levels without affecting how amisulpride worked. Someone else here at pbabble has used the D2 agonist cabergoline for the same purpose.
Posted by flip_flop on August 23, 2006, at 11:36:42
In reply to Re: Would a D2 agonist make an AP inefficient?, posted by blueberry on August 21, 2006, at 12:23:02
Titre : Usefulness of bromocriptine in the treatment of amisulpride-induced hyperprolactinemia: A case report
Titre de la Revue : Pharmacopsychiatry. [ Pharmacopsychiatry. ] , 2004 , vol. 37 , no 4 , pp. 189 - 191 [ 3 pages. ]
BLIESENER N. , YOKUSOGLU H. , QUEDNOW B. B. , KLINGMÜLLER D. , KÜHN K.-U.Type de document : PERIODIQUE Langue : anglais
Cote INIST : 14216
Editeur :
Thieme
Stuttgart
Allemagne
Résumé : We investigated the effect of bromocriptine on amisulpride-induced endocrinological disturbances (galactorrhea/amenorrhea) and on psychotic symptoms in an open-labeled study. Five women suffering from chronic psychosis and amisulpride-induced hyperprolactinemia (AIH) with amenorrhea and/or galactorrhea received bromocriptine at a dose of 10-40mg/day. In none of these patients could prolactin levels be reduced to the normal range. They were markedly reduced in three of five patients. Menses recurred in one of four patients with amenorrhea. Lactation decreased in one of three patients with galactorrhea. In two patients with reduced prolactin levels, psychotic symptoms exacerbated but fully remitted after discontinuation of bromocriptine therapy. Thus, bromocriptine seems to annihilate the central effect of amisulpride at a dose that reduces AIH. Therefore, bromocriptine appears not to be suited for the treatment of AIH.
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