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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Questionmark on October 6, 2006, at 17:55:02
Could adding tianeptine (Stablon) to Nardil mitigate some of its side effects and/or augment it do you think?
Thank you.
Posted by psychobot5000 on October 6, 2006, at 22:03:45
In reply to Nardil + tianeptine, posted by Questionmark on October 6, 2006, at 17:55:02
The tianeptine manufacturer's information says not to combine with MAOis, but my doc is of the opinion that this is just for law-suit related reasons. No one wants an MAO related legal issue on their hands.
I don't know whether it would help, but I believe it to be safe. Tianeptine is a very easy med to add to others, but you rarely know what's going to happen when you do, because of its differing mechanism of action. It sounds worth a try--might help with nausea, or other side-effects caused by serotonin excess, or increase antidepressant effects maybe...hard to say. To my knowledge, these two drugs just haven't been studied together. Maybe someone else will have a better idea.
Posted by foreigner on October 7, 2006, at 0:51:06
In reply to Re: Nardil + tianeptine, posted by psychobot5000 on October 6, 2006, at 22:03:45
I don't know It is related but I am using tianeptine(2*12,5mg) with prozac(5mg) for one or two weeks. I think It is working better then using only 20mg prozac(I hasn't worked for me) or only tianeptine . If there are people who combine tianeptine with something else I want to know too.
Posted by psychobot5000 on October 8, 2006, at 10:41:52
In reply to Re: Nardil + tianeptine, posted by foreigner on October 7, 2006, at 0:51:06
I have taken it with psychostimulants--amphetamine and methylphenidate, with some success. No noticeable interactions or other problems. I've also taken it with Lamictal, with no problems--except my body's disappointing response to the Lamictal. I've also combined it with sleep medications--Lunesta, Rozerem, and antihistamines, often concurrently with the psychostimulants or Lamictal, too. No problems.
I am -very- interested and glad to hear that it works well in combination with fluoxetine for you. I don't know what that says about these drugs, but it's probably something important.
Posted by Declan on October 8, 2006, at 23:11:26
In reply to Re: tianeptine with other meds, posted by psychobot5000 on October 8, 2006, at 10:41:52
Tianeptine plus deprenyl is OK (1mg sublingual). Insomnia resulted.
Might try Hydergine with it.
Posted by tessellated on October 14, 2006, at 14:44:20
In reply to Re: tianeptine with other meds, posted by Declan on October 8, 2006, at 23:11:26
tried tianeptine w/parnate.
no psysiological issues experienced.
though i've combined parnate with everything youre not suppose to and have never had a hypertensive reaction: except, SSRI's, tricyclics, ephedra products, banapeels, yeast extract, blue cheese, or mixed otc sleep meds. not something i'd advise, but i've used psychostimulants, beer/wine/pizza, soyproducts, etc, and provigil, wellbutrin, adrafanil, as augments, so either this tyramine reaction is way overblown, or i'm not overly sensitive to that SE.
however, i seem to have had some odd perceptual effects.
psuedohallucinogenic effects occured, though its impossible to determine if this was due to the tianeptine, or high dose parnate 100mg/24hr withdrawal. parnate w/drawal was the most likely culprit, being very similar to amphetamine psychosis.8ed
Posted by sukarno on October 24, 2006, at 10:39:08
In reply to Re: tianeptine with other meds, posted by tessellated on October 14, 2006, at 14:44:20
Tianeptine accelerates the reuptake of serotonin and increases levels of dopamine in the nucleus accumbens and cortex. SSRIs such as Prozac inhibit the reuptake of serotonin and tend to lower dopamine.
Since the action of tianeptine is the opposite of SSRIs, I am not sure that one would receive a satisfactory response when taking it along with an SSRI.
I believe the reason why MAOIs are contraindicated with conventional tricylic antidepressants and SSRIs is because those drugs inhibit the reuptake of serotonin, thus flooding the brain with this excitatory neurotransmitter. Monoamine oxidase breaks down serotonin and dopamine as far as I know, so taking an SSRI or TCA (thus boosting serotonin levels in the brain) and then inhibiting monoamine oxidase so it cannot remove this excess amount would be dangerous.
One would imagine that this may lead to the serotonin syndrome.
With tianeptine though I doubt that MAO inhibition would have much effect. Tianeptine does not cause serotonin syndrome...that's for certain.
This is the end of the thread.
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