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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by medievil on December 26, 2006, at 3:33:46
is it because of serotonin syndrome? cant i add in dxm very slowly (for its anti NMDA properties)
Posted by willyee on December 26, 2006, at 3:47:51
In reply to Why no DXM with a maoi?, posted by medievil on December 26, 2006, at 3:33:46
> is it because of serotonin syndrome? cant i add in dxm very slowly (for its anti NMDA properties)
Yes SS Syndrome here is VERY real,and this is one interaction very much WARRENTED.
Aside from imiprimine,this drug almost killed me,when i made the mistake of using it while on a Maoi,these were the things i noticed....
I started to trip,i seen worms appearing around me,little white ones
I couldent sleep,when i closed my eyes,color patterns emerged like the media play of WINDOWS,very scary.
Then the more dangerous symptoms.....
My teeth began to chatter,like i was cold,i couldent stop it.
My body twitched.
My legs twitched quite badly.
I truly felt had i taken more of DXM id had put myself in ER,if i was lucky,.....meaning the possability of DEATH wasnt a far thought.
ALSO JUST FYI,but we lost a member here due to the use of dxm,this and aspirin brought him to his passing.DXM is a very scary substance,def one to avoid while on a Maoi,the high even is not,NOT PLEASEANT,and its just very dangerous!
Posted by medievil on December 26, 2006, at 3:52:14
In reply to Re: Why no DXM with a maoi?, posted by willyee on December 26, 2006, at 3:47:51
well, i dont wonna use it to trip, but a small dose for NMDA antagonism
i'm gonna start on dxm today, and we'll see if i stop it before adding in parnate (wich is not all that serotogenic)
there's a danger but i heared tricyclics are combined with maoi's so this should work too?
if done very slowly?i'l be carefull!
Posted by Quintal on December 26, 2006, at 20:36:34
In reply to Re: Why no DXM with a maoi?, posted by medievil on December 26, 2006, at 3:52:14
Medievil, your'e being very complacent about combining contrindicated substances with MAOIs lately. Yes, some people have very rarely combined a variety of these subastances with MAOIs, but they almost certainly did so under close medical supervision - in hospital with vital signs being monitored every few minutes with resuccitation equipment on standby.
>there's a danger but i heared tricyclics are combined with maoi's so this should work too?
if done very slowly?No, not at all. Some serotogenic tricyclics such as clomipramine are completely contraindicated with MAOIs. You could administer aged cheese very carefully and slowly yet still have a hypertensive crisis.
Why are you determined to experiment with such dangerous combinations when you don't yet know what your response will be to Parnate alone?
__________________________________________________
Drug-Drug Interactionsdextromethorphan and tranylcypromine (major Drug-Drug)
Description:
CONTRAINDICATED: Monoamine oxidase inhibitors (MAOIs) may potentiate the activity of serotonergic agents such as serotonin reuptake inhibitors, 5-HT1 receptor agonists, ergot alkaloids, buspirone, dextromethorphan, and most antidepressants. The result may be an increased risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors and characterized by symptoms such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia. The mechanism is an additive pharmacodynamic effect resulting from MAOI inhibition of serotonin metabolism.
MANAGEMENT:
In general, serotonergic agents should not be used concurrently with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with serotonergic agents. A washout period of 7 to 14 days minimum is recommended when switching from another antidepressant to an MAOI.
http://www.drugs.com/xq/cfm/pageID_1150/int_1/list_1/values_drugid%3Dd00207%26drugid%3Dd00884%26/OpText_Parnate/dr_%2Cdextromethorphan%2CParnate/qx/index.htm
__________________________________________________There are other NMDA antagonists and similar drugs that affect the NMDA receptors like Lamictal that can be safely combined with MAOIs.
Q
Posted by medievil on December 27, 2006, at 7:31:47
In reply to Re: Why no DXM with a maoi? » medievil, posted by Quintal on December 26, 2006, at 20:36:34
hmm, i'l read about lamictal
problem is most nmda antagonists are so expensive...
Posted by willyee on December 27, 2006, at 12:05:12
In reply to Re: Why no DXM with a maoi?, posted by medievil on December 27, 2006, at 7:31:47
> hmm, i'l read about lamictal
> problem is most nmda antagonists are so expensive...No,i dident mean about tripping,and i HOPE most people who wanna get loaded choose a better way,even some beer.
Anyway i for example consider depression treated poorly a danger of its own,so i am one who has danced that fine maoi line many many times.
And yess parnate can be forgiving,least with a lot of the recomended foods,HOWEVER i again and lastly urge you not to play with dxm and parnate.
Even on the vault of Erowid,where experianced drug users speak,also warn aganist this.Even drug users not looking for therputic means,again im not placing u in this category,BUT even these users mostly agree that dxm is a crappy crappy dangerous toxic drug.
As far as maois go,i have found most substances are exgarated as far as the extent they are warned,this said,i still dont apply my experiance as law,fore lots of people have had problems with parnate on there first day of use.
Best thing is not to mess with a maoi unless you have been on it long enough to know how it feels,and reconize a interaction,i do and take quick action if i ever feel one happening.Luckly ive been safe here.
I agree though,i find parnate alone useful only at the start,and most people end up augmenting it.Good luck,be safe.
This is the end of the thread.
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