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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by mattye on April 8, 2007, at 22:21:03
I remember reading somewhere that recent research has shown that Wellbutrin has less effect on dopamine than previously advertised . . . that it primarily works on norepinepherine and its effect on dopamine is negligible.
Is this true?
Posted by Sebastian on April 8, 2007, at 22:50:54
In reply to Wellbutrin - negligible dopamine effect?, posted by mattye on April 8, 2007, at 22:21:03
yes it is. And I belive thats what they have been saying for the last 4 years.
Posted by Phillipa on April 9, 2007, at 12:04:36
In reply to Re: Wellbutrin - negligible dopamine effect?, posted by Sebastian on April 8, 2007, at 22:50:54
Really I thought it was dopamine too? Love Phillipa
Posted by Sebastian on April 9, 2007, at 12:38:08
In reply to Re: Wellbutrin - negligible dopamine effect? » Sebastian, posted by Phillipa on April 9, 2007, at 12:04:36
Thats a maybe. But most likely very little, is what I remember. Negligible.
Posted by linkadge on April 10, 2007, at 18:49:43
In reply to Re: Wellbutrin - negligible dopamine effect? » Phillipa, posted by Sebastian on April 9, 2007, at 12:38:08
From the studies I came across, on average users of ~300mg per day achieved approximatetly 35% inhibition of dopamine reuptake. So yes you are going to get appreciable effect on dopamine uptake, but it is questionable as to wheather this totally accounts for clinical effect.
Linkadge
Posted by psychobot5000 on April 11, 2007, at 19:02:05
In reply to Re: Not negligable, but not primary effect (?), posted by linkadge on April 10, 2007, at 18:49:43
> From the studies I came across, on average users of ~300mg per day achieved approximatetly 35% inhibition of dopamine reuptake. So yes you are going to get appreciable effect on dopamine uptake, but it is questionable as to wheather this totally accounts for clinical effect.
>
> LinkadgeIf I remember right, however, bupropion also decreases dopamine release, leaving a net-effect of a more slight increase in extrasynaptic dopamine.
This is the end of the thread.
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