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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Franz on September 11, 2007, at 13:29:46
Hello, is there any problem to take say alprazolam or bromazepam at night and clonazepam in the morning?. All in small doses.
Clonazepam alone tends to depress me.
I need anti-anxiety during the day and rthe small dose alprazolam 0.25mg or bromazepam 1.5 mg I take sometimes is not enough so I thought adding 1.25 mg clonazepam in the morning will help.
Better ideas?
Thanks
Posted by Phillipa on September 11, 2007, at 19:42:07
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
About 5 years ago my pdoc one not in this area had me on xanax during the day and xanax and klonopin very low dose at night as it depresses me also. Phillipa
Posted by CareBear04 on September 13, 2007, at 10:45:32
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
Yeah, I've had depression with Klonopin building up from taking it during the day. If you're going to mix them, I'd agree with Philippa and take the Klonopin before bed and Xanax during the day. Good luck!
CB
Posted by Maria3667 on September 13, 2007, at 16:37:23
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
Hi Franz,
My p-doc told me the golden rule with benzo's is to avoid taking them together. Combining benzo's would speed up tolerance.
Hope this information is of use to you.
My best,
Maria> Hello, is there any problem to take say alprazolam or bromazepam at night and clonazepam in the morning?. All in small doses.
> Clonazepam alone tends to depress me.
> I need anti-anxiety during the day and rthe small dose alprazolam 0.25mg or bromazepam 1.5 mg I take sometimes is not enough so I thought adding 1.25 mg clonazepam in the morning will help.
> Better ideas?
> Thanks
Posted by cloudnine on September 14, 2007, at 0:59:13
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
No problem at all.They are all chemically more similarities than differences.The only thing to keep in mind is the augmenting effect. Say if you take 1 mg Klonopin which is roughly about 2mg xanax,you may want to lower clonopin to 0.5 and add 1mg.
I combined different benzo together.eg. I'd take 0.5 mg xanax b4 sleep,then 3mg bromaxepam in the day,as my experience showed me that bromazepam is the best benzo to use during the day.It is less sedating than any benzo (except Clobazam,which is horrible),and bromaxepam tend to shorten sleeo after few days,it is like more stimulating.But Xanax hasmore consisten hypnotic effect,while it is more sdeating and tend to make a mental fog during the day.As for Clonazepam,yuck,I will never touch this one again,everytime I took it it made me blue,depressed and unmotivated.It is dfenitly a pro depressive benzo,like clorazepate,wile I find only bromazepam and alprazolam are the only benzos with mood elevating,mild antidepressant like effect.Mind you I took many many types of benzo ,from the famous ones such as valihm,ativan..etc to unkown ones like bentazepam,cinolazepam,cloxazolam,ketazolam,prazepam.......etc.
Posted by blueboy on September 16, 2007, at 11:24:15
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
There are two problems. First, obviously, you need to make informed total-dosage decisions, since they are not dosage-equivalent.
Second, they are absorbed and eliminated at different rates, which makes it quite complicated. Like drinking scotch and beer; if you drink beer or champagne after you've been drinking scotch for a few hours, you are going to get a huge spike in blood alcohol.
By the way, clonozepam doesn't depress me at all. Just the opposite. I theorize that it's because part of my depression symptoms are reactive to anxiety, or that my neurotransmitters are able to regulate better with a restful night of sleep.
Posted by cactus on September 16, 2007, at 22:45:16
In reply to Re: Is there any problem with mixing benzodiazepin, posted by blueboy on September 16, 2007, at 11:24:15
I have mixed diazepam with nitrazepam with clonazepam and have been fine. I have also mixed triazolam with these meds too and quite a few others with no ill effects
Posted by Phillipa on September 17, 2007, at 19:22:50
In reply to Re: Is there any problem with mixing benzodiazepines?, posted by cloudnine on September 14, 2007, at 0:59:13
Klonopin depressed me too. Actually first day felt suicidal and wasn't so back to the xanax at the time and was fine. We're all so different. Phillipa
Posted by Franz on September 17, 2007, at 22:21:11
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
Thanks to all.
It seems I am not the only one with problems with clonazepam. It is noticeable how sometimes it flattens affect. Good for when you have to do things you do not want to do like boring tasks. Maybe this drug is more depressing when we have some some depressive feelings.
The problem with alprazolam at night is that I feel when it starts to work and it improves mood and this does not make it easier to go to sleep.
Maybe I will stick with bromazepam at night. A good benzo IMO. And yes, I also feel benzos tend to shorten sleep.
During the day I am trying Lemon Balm (Melissa) because I read it is relaxing and enhances mood (works in nicotinic and muscarinic receptors it seems). I tried it today and it helped.
Posted by cactus on September 18, 2007, at 0:30:14
In reply to Re: Is there any problem with mixing benzodiazepines?, posted by Franz on September 17, 2007, at 22:21:11
I found clonazepam to be very depressing while I was drinking, not that I'm saying you are!!!! But since I quit drink it has been wonderful for me
Posted by Franz on September 18, 2007, at 0:47:52
In reply to Re: Is there any problem with mixing benzodiazepin » Franz, posted by cactus on September 18, 2007, at 0:30:14
> I found clonazepam to be very depressing while I was drinking, not that I'm saying you are!!!! But since I quit drink it has been wonderful for me
Thanks cactus. Sometimes I drink a bit of wine. I will try to avoid it when I take K.
Posted by Franz on September 18, 2007, at 1:17:48
In reply to Is there any problem with mixing benzodiazepines?, posted by Franz on September 11, 2007, at 13:29:46
Too bad it seems Lemon Balm is not good for thyroid. I take T4 for sub clinical hypothyroidism.
Antithyrotropic Effect: In animal models, lyophilized extracts of lemon balm have shown antithyrotropic effects.4 Unidentified components of lemon balm have the ability to bind to thyroid stimulating hormone (TSH) and render it incapable of binding to its receptors in vitro.15 Immunoglobulins (IgG) obtained from nine patients with Graves' disease were shown to inhibit the interaction of TSH with its receptors in a dose-dependent manner. Circulating IgG in plasma binds to TSH receptors and thus prevents TSH from binding to its receptors. Components in lemon balm bind to TSH receptors and preclude IgG or TSH binding to receptors. Caffeic acid present in lemon balm produced similar inhibitory effect on IgG binding.4
Do you think this is a real problem?.
Posted by Franz on May 20, 2008, at 21:01:05
In reply to Lemon Balm and thyroid, posted by Franz on September 18, 2007, at 1:17:48
> Too bad it seems Lemon Balm is not good for thyroid. I take T4 for sub clinical hypothyroidism.
>
> http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Feat/LemonBalm.htm&pub_id=8&article_id=869
>
> Antithyrotropic Effect: In animal models, lyophilized extracts of lemon balm have shown antithyrotropic effects.4 Unidentified components of lemon balm have the ability to bind to thyroid stimulating hormone (TSH) and render it incapable of binding to its receptors in vitro.15 Immunoglobulins (IgG) obtained from nine patients with Graves' disease were shown to inhibit the interaction of TSH with its receptors in a dose-dependent manner. Circulating IgG in plasma binds to TSH receptors and thus prevents TSH from binding to its receptors. Components in lemon balm bind to TSH receptors and preclude IgG or TSH binding to receptors. Caffeic acid present in lemon balm produced similar inhibitory effect on IgG binding.4
>
> Do you think this is a real problem?.
I have the same question, sorry to repeat.Today I was feeling very bad and took a tablet of valerian+melissa and felt much better.
Do you think 80-160 mg LB extract can affect thyroid too much?.
Thanks.
Posted by Franz on May 20, 2008, at 21:03:32
In reply to Re: Lemon Balm and thyroid, posted by Franz on May 20, 2008, at 21:01:05
This is the end of the thread.
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