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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Bob on December 13, 2007, at 0:18:11
Much to my chagrin, I have noticed in the last few years that I seem to have developed an intolerance for antidpressants that have an action in norepinephrine. The two most egregious offenders being Welbutrin and now Cymbalta. They produce a tightness in my upper chest and throat along with a depressed difficulty in breathing, like a weight is on my chest. The very unfortunate part is that norepinephrine manipulation seems to be the only thing that has given me any kind of energy. Even coffee does this to me to a certain extent.
In the aforementioned examples, the cardivascular effects usually have a delayed onset. At first there is an increase in my energy, and then as the blood levels are decreasing, the tightness and breathing effects set in.
I have many problems with serotonergic compounds also, which seems to pretty much leave me with little or no options for monamine compounds.
Posted by cumulative on December 13, 2007, at 2:00:19
In reply to breathing difficulties, posted by Bob on December 13, 2007, at 0:18:11
-- anxiety (not really surprising for norepinephrine stuff)
-- how's your blood pressure?
-- possible but, extremely rare vascular issuesIf anything, something with peripheral norepinephrine activity should be bronchodilating, not constricting.
Posted by Phillipa on December 13, 2007, at 11:52:55
In reply to breathing difficulties, posted by Bob on December 13, 2007, at 0:18:11
Bob have you had your heart Ekg done? I don't know your age but today age really doesn't have that much effect on cardiovascular problems. I'm sure you're fine. If not sounds like anxiety to me. And how is your bp? Phillipa
Posted by Bob on December 13, 2007, at 12:04:43
In reply to some possibilities to consider, posted by cumulative on December 13, 2007, at 2:00:19
> -- anxiety (not really surprising for norepinephrine stuff)
> -- how's your blood pressure?
> -- possible but, extremely rare vascular issues
>
> If anything, something with peripheral norepinephrine activity should be bronchodilating, not constricting.I'd have to say that I don't feel the least bit anxious when it is happening, but it does seem to be related to activity. I get muscle weakness along with the breathing problems, and have to sit or lie down. Then it ebbs away.
This problem has been most prominent with Welbturin and Cymbalta (It did rear its ugly head when I added T3 and T4 to Celexa a little). I've had my blood pressure done multiple times and it hasn't been a problem. I've had full physicals more than once and nothing has been found.
"Extremely rare vascular issues"... such as?
Posted by Bob on December 13, 2007, at 12:07:39
In reply to Re: breathing difficulties » Bob, posted by Phillipa on December 13, 2007, at 11:52:55
> Bob have you had your heart Ekg done? I don't know your age but today age really doesn't have that much effect on cardiovascular problems. I'm sure you're fine. If not sounds like anxiety to me. And how is your bp? Phillipa
Phillipa,
I had a robust course of ECT about 2 years ago, and naturally had more than one ECT. They were utterly normal.
It almost seems to be realted to muscle effort, rather than anxiety to me. If I exert myself physically, there will often be a delayed onset of this breathing difficulty and muscle weakness.
Bob
Posted by Phillipa on December 13, 2007, at 19:12:08
In reply to Re: breathing difficulties, posted by Bob on December 13, 2007, at 12:07:39
Have you seen a neurologist? Reminds me of a horrible illness mother-in-law had. Phillipa
Posted by Bob on December 13, 2007, at 21:37:24
In reply to Re: breathing difficulties » Bob, posted by Phillipa on December 13, 2007, at 19:12:08
> Have you seen a neurologist? Reminds me of a horrible illness mother-in-law had. Phillipa
Haven't seen a neurologist recently, actually.
This is the end of the thread.
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