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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Phil on October 7, 2008, at 16:45:45
My pdoc's concerned about staying at 90mg because of it's effect on the liver. I don't have any reason to doubt him but I need a second opinion.
Posted by Phillipa on October 7, 2008, at 16:52:37
In reply to Is Cymbalta especially hard on the liver?, posted by Phil on October 7, 2008, at 16:45:45
Phil check google as I was seriously surprised to see it affects the liver as was on it before. I'd get liver enyme tests done. Keep an eye on it. Phillipa
Posted by Phil on October 7, 2008, at 17:58:21
In reply to Re: Is Cymbalta especially hard on the liver? » Phil, posted by Phillipa on October 7, 2008, at 16:52:37
Posted by azalea on October 7, 2008, at 19:10:44
In reply to Is Cymbalta especially hard on the liver?, posted by Phil on October 7, 2008, at 16:45:45
From the article below, it seems like you're at increased risk if you drink alcohol or have liver problems before taking Cymbalta.
Postgrad Med. 2008 Jul;120(2):111-8.
Answers to the most common questions about the hepatic safety profile of duloxetine.
Since its first FDA approval in 2004, duloxetine has been taken by more than 5 million patients. A small fraction of patients treated with duloxetine develop elevations in liver enzymes, which generally resolve spontaneously without any change in treatment. Very rare cases (estimated 1-2 per 100,000 exposures) of idiosyncratic hepatic toxicity have been reported in patients taking duloxetine, particularly in those with substantial alcohol use and/or preexisting liver disease. In the context of more than 23,000 patients exposed during clinical trials, and more than 1.5 million patient years of exposure subsequent to product launch, the hepatic risk after exposure to duloxetine appears to be within the range identified for other therapeutic agents. Therefore, it does not warrant hepatic enzyme monitoring. As with any medication, physicians should follow prescribing guidelines and educate patients on the risks and benefits of duloxetine.
> My pdoc's concerned about staying at 90mg because of it's effect on the liver. I don't have any reason to doubt him but I need a second opinion.
Posted by Phil on October 8, 2008, at 9:25:31
In reply to Re: Is Cymbalta especially hard on the liver? » Phil, posted by azalea on October 7, 2008, at 19:10:44
Thanks azalea, No liver problems and I haven't drank since I was put on meds over 20 years ago.
I sure could use a margarita! :)
Posted by rskontos on October 8, 2008, at 9:34:57
In reply to Re: Is Cymbalta especially hard on the liver? » azalea, posted by Phil on October 8, 2008, at 9:25:31
Phil, the liver filters many drugs from our body. The liver performs many complex functions. Some of these are:
* To convert food into chemicals necessary for life and growth.
* To manufacture and export important substances used by the rest of the body.
* To process drugs absorbed from the digestive tract into forms that are easier for the body to use.
* To detoxify and excrete substances that would otherwise be poisonous.
* To regulate cholesterol.So most drugs go through the liver at some point. Cymbalta, according to my neuro, also says in the body for quite some time.
rsk
This is the end of the thread.
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