![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by morganator on August 22, 2009, at 0:05:18
I was wondering which antidepressants might be safer/healthier for the brain and body long term, SSRI's or MAOIs,specifically Parnate and Nardil.
Posted by Phillipa on August 22, 2009, at 0:32:25
In reply to Healthier Long Term-MAOIs or SSRIs???, posted by morganator on August 22, 2009, at 0:05:18
I personally feel neither could be healthy as all chemicals. Phillipa
Posted by SLS on August 22, 2009, at 7:23:44
In reply to Healthier Long Term-MAOIs or SSRIs???, posted by morganator on August 22, 2009, at 0:05:18
> I was wondering which antidepressants might be safer/healthier for the brain and body long term, SSRI's or MAOIs,specifically Parnate and Nardil.
>I don't know what the final judgment will be, but MAOIs can help prevent apoptosis and cell death. This includes Nardil and Parnate, and not only selegiline (Emsam; Eldepryl) and rasagiline (Azilect). However, the latter two drugs seem to demonstrate a more robust antiapoptotic neuroprotective effect. It is interesting that MAO activity increases with age.
There are some studies pointing to elevated serotonin levels increasing mitochondrial damage and apoptosis, particularly with fluoxetine (Prozac). Damage to cardiac endothelial cells has been seen in people who possess the SS gene variant (allele) of the serotonin transporter.
I really don't know how to interpret all of this. Outside the lab and in real life, are these studies relevant? Although they are inferior antidepressants, selegiline and rasagiline both show the highest degree of neuroprotection. Of these, rasagiline has the advantage of not producing methamphetamine, a pro-apoptotic, as a metabolite.
- Scott
Posted by SLS on August 22, 2009, at 8:40:49
In reply to Re: Healthier Long Term-MAOIs or SSRIs???, posted by SLS on August 22, 2009, at 7:23:44
> There are some studies pointing to elevated serotonin levels increasing mitochondrial damage and apoptosis, particularly with fluoxetine (Prozac). Damage to cardiac endothelial cells has been seen in people who possess the SS gene variant (allele) of the serotonin transporter.
I should note that there aren't more than a handful of studies dedicated to examining these things, and that more intensive investigations are required to corroborate them and to establish firm associations and elucidate the mechanisms that might be responsible for these observations.I would still not hesitate to use an SRI if it were the only drug that I would respond to. If it comes down to it, I would mix Pristiq with nortriptyline.
- Scott
Posted by morganator on August 22, 2009, at 21:07:00
In reply to Re: Healthier Long Term-MAOIs or SSRIs???, posted by SLS on August 22, 2009, at 8:40:49
Would you consider the feeling of being on an MAOI to be considerably different than an SSRI over the long run?
Posted by SLS on August 23, 2009, at 3:12:00
In reply to Re: Healthier Long Term-MAOIs or SSRIs???, posted by morganator on August 22, 2009, at 21:07:00
> Would you consider the feeling of being on an MAOI to be considerably different than an SSRI over the long run?
I think the MAOI is cleaner. It feels cleaner in that there is no lingering brain fog or numbing effects.
- Scott
Posted by bulldog2 on August 23, 2009, at 14:35:41
In reply to Healthier Long Term-MAOIs or SSRIs???, posted by morganator on August 22, 2009, at 0:05:18
> I was wondering which antidepressants might be safer/healthier for the brain and body long term, SSRI's or MAOIs,specifically Parnate and Nardil.
>I believe nardil or parnate as they preserve all the neurotransmitters... ssris are suspected of shutting down dopamine and that is bad for the entire body...that disrupts hormonal balance
Posted by bulldog2 on August 23, 2009, at 14:38:38
In reply to Healthier Long Term-MAOIs or SSRIs???, posted by morganator on August 22, 2009, at 0:05:18
> I was wondering which antidepressants might be safer/healthier for the brain and body long term, SSRI's or MAOIs,specifically Parnate and Nardil.
>ah forgot emsam (selegiline). Studies have been done on mice that seem to indicate this med may lengthen life span and improve brian function
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.