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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by pedr on September 19, 2009, at 19:15:46
Hi gang,
Wikipedia says the following on its Nardil page:
"Although phenelzine has a relatively short half-life (approximately 1.2 hours), unlike most other drugs, phenelzine irreversibly disables MAO, and as a result, it does not necessarily need to be present in the blood at all times for its effects to be sustained."Does this mean that it makes no difference whatsoever, in terms of its efficacy, whether I take my daily amount in one go, or 1 pill every two hours or any variant thereof?
I ask because it just occurred to me that I take 2 x 15mg before bed (11pm) and 3 x 15mg when I get up (7am) which is a period of only 8 hours, leaving 16 hours without a dose. I've been doing this through habit mainly.
Thanks,
Pete
Posted by atypical on September 20, 2009, at 15:18:12
In reply to Nardil dosage times irrelevant?, posted by pedr on September 19, 2009, at 19:15:46
Pete,
Generally they say Nardil doses should be split throughout the day rather than taken all at once. I'm sure you can take it all at once though if you wanted to. I take 75mg of Nardil. I realized back when I was taking 60 that if I took it all at once I would get more side effects -- more fatigue. So I split the dose to 30 twice a day. I split the 75 dose to 1 in morning, 2 at midday, and 2 at night. I find that this reduces the side effects for me. As far as efficacy, I have no idea if this makes a difference. I'm feeling pretty good so I guess it works!
Atypical
Posted by pedr on September 22, 2009, at 16:12:35
In reply to Re: Nardil dosage times irrelevant?, posted by atypical on September 20, 2009, at 15:18:12
Thanks Atypical.
You say you're feeling pretty good - how much of an improvement have you experienced? I am much, much better overall but all of the problems I had before such as obsessional blame, anxiety, very painful irrational beliefs, self-loathing are still there. They're just less frequent and are ameliorated - less intense and less painful. I also still feel depressed for the first 2 hours of every day. Is this the case for you or has it fully addressed all of aspects of your depression?
And what about side-effects? (I'm totally hijacking my own thread here, but whatever) I have:
- extreme daytime tiredness, almost bordering on narcolepsy! I fall asleep regularly very quickly. This is not good when I'm at work...
- standing up, turning my head, walking quickly up a flight of stairs often all result in dizziness where I sometimes have to hold onto something to steady myself. This lasts about 15-120 seconds.
- sometimes it's as if someone has turned up the contrast in my vision way too high - everything becomes really bright and whites become blinding. This is often the same time as when I feel dizzy but lasts for 3+ minutes.
- my appetite, esp. the last few weeks has gone up considerably. I crave carbs and am eating tons of bagels and bread (partly also because they are OK for my IBS too). I find myself thinking about toast and bread even when I've just eaten. Very weird.Pete
Posted by pedr on September 23, 2009, at 19:08:03
In reply to Nardil dosage times irrelevant?, posted by pedr on September 19, 2009, at 19:15:46
Posted by Questionmark on September 29, 2009, at 23:37:58
In reply to Nardil dosage times irrelevant?, posted by pedr on September 19, 2009, at 19:15:46
Forget any theoretical mumbo jumbo that might suggest it is just as well to take all your Nardil doses at once.
From my multi-year, revolving-dose, obsessively over-analytical observations and experience with Nardil, i have no doubt that the more you can spread your doses out throughout the day, the better.
In my opinion, a *minimum* of 3x per day is ideal, as frustratingly inconvenient as that is.
> Hi gang,
> Wikipedia says the following on its Nardil page:
> "Although phenelzine has a relatively short half-life (approximately 1.2 hours), unlike most other drugs, phenelzine irreversibly disables MAO, and as a result, it does not necessarily need to be present in the blood at all times for its effects to be sustained."
>
> Does this mean that it makes no difference whatsoever, in terms of its efficacy, whether I take my daily amount in one go, or 1 pill every two hours or any variant thereof?
>
> I ask because it just occurred to me that I take 2 x 15mg before bed (11pm) and 3 x 15mg when I get up (7am) which is a period of only 8 hours, leaving 16 hours without a dose. I've been doing this through habit mainly.
>
> Thanks,
> Pete
Posted by pedr on October 1, 2009, at 9:13:24
In reply to Re: Nardil dosage times irrelevant? » pedr, posted by Questionmark on September 29, 2009, at 23:37:58
> Forget any theoretical mumbo jumbo that might suggest it is just as well to take all your Nardil doses at once.
Theoretical mumbo jumbo, lol.
> From my multi-year, revolving-dose, obsessively over-analytical observations and experience with Nardil, i have no doubt that the more you can spread your doses out throughout the day, the better.
> In my opinion, a *minimum* of 3x per day is ideal, as frustratingly inconvenient as that is.
>Perfect, this is exactly the kind of info I was looking for - someone who's been there and got the T-shirt. I too get obsessive about dosing times, proportions, whether to eat with food, how long to leave before taking other meds/vitamins. It's driven for me by the fact that I have some very good days that I sail through and I have some truly miserable days where my OCD and anxiety kicks my *ss. I often feel that the factors listed above have a real effect on that.
Thanks for the post, I will give 3x a day a go. Bit nervous about trying it since the last time (perhaps co-incidentally) I changed my dosing schedule, I crashed for 4 days quite spectacularly.
Pete
> > Hi gang,
> > Wikipedia says the following on its Nardil page:
> > "Although phenelzine has a relatively short half-life (approximately 1.2 hours), unlike most other drugs, phenelzine irreversibly disables MAO, and as a result, it does not necessarily need to be present in the blood at all times for its effects to be sustained."
> >
> > Does this mean that it makes no difference whatsoever, in terms of its efficacy, whether I take my daily amount in one go, or 1 pill every two hours or any variant thereof?
> >
> > I ask because it just occurred to me that I take 2 x 15mg before bed (11pm) and 3 x 15mg when I get up (7am) which is a period of only 8 hours, leaving 16 hours without a dose. I've been doing this through habit mainly.
> >
> > Thanks,
> > Pete
>
>
Posted by GreenP on April 8, 2010, at 22:22:22
In reply to Re: Nardil dosage times irrelevant?, posted by pedr on October 1, 2009, at 9:13:24
Hi all. Thought this might interest you...
"Phenelzine is administered orally in the form of phenelzine sulfate and is rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration is 43 minutes and half-life is 11.6 hours. "
So what this means is that the half life is about 12 hours. For this reason I take doses at two polar times of the day (one at 8 AM and the other at 8 PM).
Hope that helps!
P
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