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Dr. Bob is Robert Hsiung, MD,
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Posted by iforgotmypassword on November 6, 2009, at 6:23:17
Does anyone know of many benign 3A4 inhibitors, and measures of potency of 3A4 inhibition?
I am taking nefazodone (Serzone) to increase buspirone levels. 3A4 inhibition increases buspirone dramatically while decreasing 1-PP in the blood. While this sounds like what I want, and isn't contraindicated (the instructions are to start low), nefazodone is apparently a 5-HT1a antagonist, as it seems are it's metabolites (though I can't find hard measures of its intrinsic efficacy). I am worried this in fact decreases VTA firing or at least precludes any increase, prevents the lowering of 5-ht, banishing buspirone from relevant receptors (presynaptic) and structures for me.
I am not been having the response I had 1 and a half days after discontinuing high dose nefazodone accidentally a long time ago, which is the most palpably beneficial I have experienced.
Need to think of what to try. SSRIs are always a disaster, and fluvoxamine gives me immediate shivers. (A symptom of serotonin syndrome.)
I mean I'd love some flibanserin, which may potentially be one of the most effective and targeted antianhedonics ever, but...
Or tandospirone, but...
And I can't find much exacting info on 3A4 inhibition by quercetin or bergamottin that makes me feel confident using either...
This is the end of the thread.
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