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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by kirbyw on March 16, 2010, at 18:33:01
Here is a recent article about how mao inhibitors may actually help fight heart disease. As a long time MAO user, and a person for whom other meds have not worked, it is amazing to actually see a potentially postive side effect of this drug. There are so many negatives as many of you are aware. And as someone who has had by-pass surgery, this seems to be "just what the Doctor ordered" Of course, I am not sure about the scientific aspects of this study in terms of how 30 mg daily of Parnate would relate to the study's findings.
But in general its good news. It will be interesting to see if millions of heart disease patients will soon be taking MAO's!
Rick in Costa Rica.
Posted by linkadge on March 17, 2010, at 8:06:06
In reply to MAO inhibitors and heart disease: a new study., posted by kirbyw on March 16, 2010, at 18:33:01
The drug used clorgyline appears to work for heart enlargement. Will other MAOI's work, maybe, maybe not.
Linkadge
Posted by floatingbridge on March 17, 2010, at 10:49:06
In reply to MAO inhibitors and heart disease: a new study., posted by kirbyw on March 16, 2010, at 18:33:01
Hi Rick, thanks for posting. There seem to be some serious pluses that go along with MAOI usage--at least compared w/ some other treatments. Hope you are well.
Posted by Netch on March 17, 2010, at 10:53:53
In reply to MAO inhibitors and heart disease: a new study., posted by kirbyw on March 16, 2010, at 18:33:01
Interesting, monoamine catabolites are toxic.
Monoamine transporters seem to be there for a reason.
Posted by SLS on March 17, 2010, at 11:37:52
In reply to Re: MAO inhibitors and heart disease: a new study. » kirbyw, posted by Netch on March 17, 2010, at 10:53:53
> Interesting, monoamine catabolites are toxic.
> Monoamine transporters seem to be there for a reason.It is important for the neuron to sequester the monoamine neurotransmitters in the synaptic vesicle to protect them from cytosolic MAO. Here, the effective operation of the vesicular amine transporter (VAT) is critical.
Interesting article. As Linkadge indicates, it will prove informative to investigate whether or not other MAOIs produce a protective or therapeutic effect in heart failure.
- Scott
Posted by linkadge on March 17, 2010, at 11:48:48
In reply to Re: MAO inhibitors and heart disease: a new study., posted by SLS on March 17, 2010, at 11:37:52
The fact that they linked the theraputic effect to decreased cardiac NE makes me wonder. I thought the purpose of the MAOI's was to potentiate neurotransmitter activity.
My heart rate doubled on parnate.
Linkadge
Posted by kirbyw on March 18, 2010, at 0:32:56
In reply to Re: MAO inhibitors and heart disease: a new study., posted by linkadge on March 17, 2010, at 11:48:48
My heart rate can be reduced or increased by Parnate. There are apprently two different contexts.
The acute and longer lasting anxiety attacks I experience when I am not taking Parnate seem to raise my heart rate as is expected. At times I am in a constant state of heightened anxiety when not on Parnate, which is bourne out by a resting heart that is above 100 or 115.
But also postural hypotension seems to increase heart rate, although Parnate will reduce or eliminate the rise in heart rate that is apparently due to the anxiety mentioned above.
Even though I am more relaxed my blood pressure is more unstable. I have noticed that low blood pressure if related to Parnate use, is correlated to a higher heart rate.
When I first get up after lying down, if I take my resting heart rate as quickly as possible it will be very high, then will drop as soon as I have been seated for a few minutes. Standing after sitting produces the same result.
I should mention that I never took my pulse (heart rate) until two years ago when I had bypass surgery, and that I am on Lopressor (a beta blocker) to control blood pressure and heart rate. But even while taking the Lopressor both of the above phenomenom occur.
Unfortunately the Lopressor also leads to a lower blood pressure when combined with Parnate than it otherwise would, but my cardiologist says I should take it anyway. So I live with a kind of constant sensation of postural hypotension for hours at a time, although not to the point of passing out.
Rick
Posted by linkadge on March 18, 2010, at 11:23:33
In reply to Re: MAO inhibitors and heart disease: a new study., posted by kirbyw on March 18, 2010, at 0:32:56
My normal heart rate is like 50. On parnate is was over 100 all the time.
Linkadge
Posted by Ron Hill on March 22, 2010, at 2:59:52
In reply to MAO inhibitors and heart disease: a new study., posted by kirbyw on March 16, 2010, at 18:33:01
Good to know that my heart will be in good shape when my liver conks out.
:-)
-- Ron
This is the end of the thread.
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