Psycho-Babble Alternative Thread 422204

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excitotoxicity and interleukin 6

Posted by raybakes on November 30, 2004, at 4:30:22

Just looking at all the places IL-6 appears!

'Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons.'


"These results support a pathological role for IL-6 in the CNS and indicate that NMDA receptor-mediated functions are likely to play a critical role in neuropathological changes observed in CNS diseases associated with elevated CNS levels of IL-6."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9852582

 

Re: excitotoxicity and interleukin 6

Posted by linkadge on December 1, 2004, at 17:07:30

In reply to excitotoxicity and interleukin 6, posted by raybakes on November 30, 2004, at 4:30:22

Correct my if I'm wrong, but doesn't magnesium act as both an NMDA antagonist, and a supresser interkeuken-6.

Linkadge

 

Re: excitotoxicity and interleukin 6 » linkadge

Posted by raybakes on December 1, 2004, at 17:37:48

In reply to Re: excitotoxicity and interleukin 6, posted by linkadge on December 1, 2004, at 17:07:30

> Correct my if I'm wrong, but doesn't magnesium act as both an NMDA antagonist, and a supresser interkeuken-6.
>
> Linkadge

Thanks Linkadge - just looked up some abstracts and found one that said that low magnesium results in an inflammatory response that triggers the release of interleukin 6 - amongst others.

So interleukin 6 and magnesium both have effects on the NMDA receptor directly, and low magnesium can, along with several other factors (inflammation, infection etc..) raise interleukin 6.

Thanks, sorry to go on about interleukin 6, but it does seem fascinating!

Ray

 

Re: excitotoxicity and interleukin 6

Posted by linkadge on December 2, 2004, at 15:27:08

In reply to Re: excitotoxicity and interleukin 6 » linkadge, posted by raybakes on December 1, 2004, at 17:37:48

I think the immune system is integral to those recovering from depression.

Linkadge

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